Virulence factor Nsp1
A major virulence factor of SARS-CoV is the non-structural protein 1 (Nsp1) which suppresses host gene expression by ribosome association (see our July 18 CR Top 10: Thoms M, Buschauer R, Ameismeier M, et al. Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2. Science 17 Jul 2020: eabc8665. Full-text: https://doi.org/10.1126/science.abc8665). The authors briefly review Nsp1’s ability to downregulate the innate immune responses. A future drug target?
Vann KR, Tencer AH, Kutateladze TG. Inhibition of translation and immune responses by the virulence factor Nsp1 of SARS-CoV-2. Sig Transduct Target Ther 5, 234 (2020). Full-text: https://doi.org/10.1038/s41392-020-00350-0
Find the Top 10 papers of the day at https://covidreference.com/top-10-october-11.